A pores and skin patch to deal with peanut allergic reactions? Research in toddlers reveals promise

A pores and skin patch to deal with peanut allergic reactions? Research in toddlers reveals promise

WASHINGTON (AP) — An experimental pores and skin patch is displaying promise to deal with toddlers who’re extremely allergic to peanuts — coaching their our bodies to deal with an unintentional chew.

Peanut allergy is among the most typical and harmful meals allergic reactions. Dad and mom of allergic tots are continually on guard towards exposures that may flip birthday events and play dates into emergency room visits.

There isn’t a treatment. The only treatment is for children 4 and older who can eat a particular peanut powder to guard towards a extreme response.

The patch, named Viaskin, goals to ship that type of remedy by means of the pores and skin as an alternative. In a significant take a look at with kids ages 1 to three, it helped those that couldn’t tolerate even a small fraction of a peanut to finally safely eat a couple of, researchers reported Wednesday.

If extra testing pans out, “this may fill an enormous unmet want,” mentioned Dr. Matthew Greenhawt, an allergist at Kids’s Hospital Colorado who helped lead the examine.

About 2% of U.S. youngsters are allergic to peanuts, some so severely than even a tiny quantity may cause a life-threatening response. Their immune system overreacts to peanut-containing meals, triggering an inflammatory cascade that causes hives, wheezing or worse. Some kids outgrow the allergy however most should keep away from peanuts for all times and carry rescue medication to stave off a extreme response in the event that they unintentionally ingest some.


In an AP interview, Dr. Matthew Greenhawt, an allergist at Kids’s Hospital Colorado who helped lead the examine, says sufferers have new choices now.

In 2020, the Meals and Drug Administration accepted the primary remedy to induce tolerance to peanuts -– an “oral immunotherapy” named Palforzia that youngsters ages 4 to 17 eat day by day to maintain up the safety. Aimmune Therapeutics’ Palforzia is also being tested in toddlers.

France’s DBV Applied sciences is pursuing skin-based immunotherapy in its place approach to desensitize the physique to allergens.

The Viaskin patch is coated with a small quantity of peanut protein that’s absorbed into the pores and skin. A day by day patch is worn between the shoulder blades, the place toddlers can’t pull it off.

Within the new examine, 362 toddlers with peanut allergy first have been examined to see how excessive a dose of peanut protein they may tolerate. Then they have been randomly assigned to make use of the Viaskin patch or a lookalike dummy patch every single day.

After a 12 months of remedy, they have been examined once more and about two-thirds of the toddlers who used the true patch may safely ingest extra peanuts, the equal of three to 4, researchers concluded.

That compares to a few third of children given the dummy patches. Greenhawt mentioned they doubtless embrace youngsters who’re outgrowing the allergy.

As for security, 4 Viaskin recipients skilled an allergic response known as anaphylaxis that was deemed associated to the patch. Three have been handled with epinephrine to calm the response, and one dropped out of the examine.

Some kids additionally unintentionally ate peanut-containing meals through the examine, and researchers mentioned allergic reactions have been much less frequent among the many Viaskin customers than these sporting the dummy patches. The most typical aspect impact was pores and skin irritation on the patch web site.

The findings have been revealed within the New England Journal of Medication.

The outcomes “are excellent information for toddlers and their households as the subsequent step towards a future with extra therapies for meals allergic reactions,” Dr. Alkis Togias of the Nationwide Institutes of Well being, which wasn’t concerned with the examine, wrote in an accompanying editorial.

Togias cautioned that it’s too early to check oral and pores and skin therapies, however pointed to knowledge suggesting every might need completely different execs and cons — elevating the likelihood that oral remedy could be stronger but in addition trigger extra negative effects.

DBV Applied sciences has struggled for a number of years to carry the peanut patch to market. Final month the corporate introduced the FDA desires some extra security knowledge for toddlers, and a separate examine already is monitoring longer remedy. A examine of 4- to 7-year-olds is also underway.


The Related Press Well being and Science Division receives assist from the Howard Hughes Medical Institute’s Division of Science Training. The AP is solely answerable for all content material.

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