A pores and skin patch to deal with peanut allergic reactions? Research in toddlers exhibits promise

A pores and skin patch to deal with peanut allergic reactions? Research in toddlers exhibits promise

A brand new examine finds an experimental pores and skin patch exhibits promise to deal with toddlers who’re extremely allergic to peanuts

WASHINGTON — An experimental pores and skin patch is displaying promise to deal with toddlers who’re extremely allergic to peanuts — coaching their our bodies to deal with an unintentional chew.

There isn’t any remedy. The one remedy is for youngsters 4 and older who can eat a particular peanut powder to guard in opposition to a extreme response.

The patch, named Viaskin, goals to ship that form of remedy by means of the pores and skin as a substitute. In a significant check with kids ages 1 to three, it helped those that couldn’t tolerate even a small fraction of a peanut to ultimately safely eat a couple of, researchers reported Wednesday.

If further testing pans out, “this could fill an enormous unmet want,” mentioned Dr. Matthew Greenhawt, an allergist at Youngsters’s Hospital Colorado who helped lead the examine.

About 2% of U.S. youngsters are allergic to peanuts, some so severely than even a tiny quantity could cause a life-threatening response. Their immune system overreacts to peanut-containing meals, triggering an inflammatory cascade that causes hives, wheezing or worse. Some kids outgrow the allergy however most should keep away from peanuts for all times and carry rescue drugs to stave off a extreme response in the event that they by chance ingest some.

In 2020, the Meals and Drug Administration accredited the primary remedy to induce tolerance to peanuts -– an “oral immunotherapy” named Palforzia that youngsters ages 4 to 17 eat every day to maintain up the safety. Aimmune Therapeutics’ Palforzia is also being examined in toddlers.

France’s DBV Applied sciences is pursuing skin-based immunotherapy in its place technique to desensitize the physique to allergens.

The Viaskin patch is coated with a small quantity of peanut protein that’s absorbed into the pores and skin. A every day patch is worn between the shoulder blades, the place toddlers can’t pull it off.

Within the new examine, 362 toddlers with peanut allergy first had been examined to see how excessive a dose of peanut protein they might tolerate. Then they had been randomly assigned to make use of the Viaskin patch or a lookalike dummy patch on daily basis.

After a 12 months of remedy, they had been examined once more and about two-thirds of the toddlers who used the actual patch might safely ingest extra peanuts, the equal of three to 4, researchers concluded.

That compares to a few third of kids given the dummy patches. Greenhawt mentioned they seemingly embrace youngsters who’re outgrowing the allergy.

As for security, 4 Viaskin recipients skilled an allergic response referred to as anaphylaxis that was deemed associated to the patch. Three had been handled with epinephrine to calm the response, and one dropped out of the examine.

Some kids additionally by chance ate peanut-containing meals in the course of the examine, and researchers mentioned allergic reactions had been much less frequent among the many Viaskin customers than these carrying the dummy patches. The commonest facet impact was pores and skin irritation on the patch web site.

The findings had been printed within the New England Journal of Medication.

The outcomes “are superb information for toddlers and their households as the following step towards a future with extra remedies for meals allergic reactions,” Dr. Alkis Togias of the Nationwide Institutes of Well being, which wasn’t concerned with the examine, wrote in an accompanying editorial.

Togias cautioned that it’s too early to match oral and pores and skin remedies, however pointed to knowledge suggesting every may need totally different execs and cons — elevating the likelihood that oral remedy is likely to be stronger but additionally trigger extra negative effects.

DBV Applied sciences has struggled for a number of years to carry the peanut patch to market. Final month the corporate introduced the FDA needs some further security knowledge for toddlers, and a separate examine already is monitoring longer remedy. A examine of 4- to 7-year-olds is also underway.


The Related Press Well being and Science Division receives help from the Howard Hughes Medical Institute’s Division of Science Training. The AP is solely accountable for all content material.

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